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When standard depression treatments haven’t done enough, new approaches may offer relief. At Peak Interactive Wellness, we specialize in caring for those with treatment-resistant depression using innovative solutions like Spravato®, ketamine-assisted psychotherapy, and personalized care plans.

Treatment Resistant Depression

Psychiatry & Medication Management located in Denver and Greenwood Village, CO

Many people with TRD still experience the same core symptoms of depression—persistent sadness, loss of interest, fatigue, sleep or appetite changes—plus additional distress from having tried treatments that didn’t help. Our goal is to find what does work for you. 

Treatment-resistant depression is a form of major depression that hasn’t sufficiently improved after trying typical antidepressant medications or psychotherapy. It means that despite treatments that work for many others, the symptoms remain severe or persist.

What is treatment-resistant depression?

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You prefer care that adjusts over time until you find what finally works.

You want help figuring out which treatment path fits your specific situation.

You’re open to exploring newer or combination treatments

You feel stuck because typical treatments haven’t made enough difference.

Your daily life is still disrupted by depressive symptoms like fatigue or hopelessness.

You’ve tried antidepressants or talk therapy without enough relief.

This Treatment May Be For You If . . .

Support at Peak Interactive Wellness starts with a psychiatric evaluation to review your history of treatments, current symptoms, medical background, and any co-occurring conditions. Treatment recommendations are tailored to your experience, because what works can vary significantly from one person to another.

Possible treatment options may include:

  • Medication management changes 
  • Ketamine-assisted psychotherapy 
  • Spravato® nasal spray use under supervision 
  • Cognitive behavioral therapy or other psychotherapy forms 
  • Holistic psychiatry and supplements where appropriate 
  • Telehealth or in-person sessions depending on what works best 

Everyone’s path is different. We’ll monitor progress, adjust as needed, and integrate supportive strategies—like lifestyle habits, sleep, and diet—to boost effectiveness and help you feel steadier over time.

What does support for treatment-resistant depression involve?

Frequently Asked Questions

What makes depression “treatment-resistant”?

Depression is considered treatment-resistant when standard treatments like antidepressants or psychotherapy haven’t resulted in adequate improvement. If you’ve tried one or more medications or different therapy approaches and are still experiencing significant symptoms, that’s often what defines TRD. Knowing this helps your care team look into other options.

What advanced treatments are offered here?

Beyond standard care, there are additional evidence-based options such as Spravato® nasal spray and ketamine-assisted psychotherapy. We adjust medication strategies, use psychotherapy, and sometimes combine multiple modalities to get better outcomes. Treatment is personalized to what you’ve tried, how you responded, and your comfort level.

How long before I might feel a difference?

Results vary widely. Some people start noticing relief within a few treatments of Spravato or ketamine; for others, improvements are slower. What’s important is that your provider checks in regularly, adjusts the plan as needed, and supports you in making steady progress, even if it takes time.

We accept most commercial insurance plans. Please contact us for more information.

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New options and individualized strategies are available.

Still facing depression that hasn’t lifted?


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