How Spravato™ Differs from Traditional Antidepressants
Exploring a new path to relief with Peak Interactive Wellness in Denver, Colorado.
Are you struggling with depression or anxiety and finding that traditional antidepressants aren’t giving you the relief you need? You’re not alone. Depression is a complex condition that often requires a tailored approach to treatment. At Peak Interactive Wellness in Denver, we understand that what works for one person may not work for another. That’s why we offer Spravato™ (esketamine) — a breakthrough treatment designed for those who haven’t found success with traditional antidepressants.
In this article, we’ll explore what Spravato is, how it works differently from standard antidepressants, and why it may be the right fit for you.
What Is Spravato™?
Spravato™ (esketamine) is an FDA-approved nasal spray prescribed to treat major depressive disorder (MDD) and treatment-resistant depression (TRD) in adults. Unlike oral antidepressants that focus on serotonin or norepinephrine, Spravato works through a completely different pathway in the brain — the glutamate system.
This novel mechanism targets NMDA (N-methyl-D-aspartate) receptors, which are involved in learning, memory, and emotional regulation. By influencing these receptors, Spravato can help create new neural connections, offering a faster-acting and more transformative approach to treating depression.
At Peak Interactive Wellness, our certified psychiatric providers administer Spravato in a safe, supportive environment where you can rest comfortably under professional supervision.
How Spravato Differs from Traditional Antidepressants
Traditional antidepressants — such as SSRIs (Selective Serotonin Reuptake Inhibitors) and SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) — work by gradually increasing neurotransmitters like serotonin or norepinephrine over several weeks. While these medications are effective for many, some individuals do not experience meaningful symptom relief even after trying multiple medications.
Here’s how Spravato stands apart:
1. Different Mechanism of Action
Rather than targeting serotonin, Spravato acts on glutamate, the brain’s most abundant excitatory neurotransmitter. This mechanism is believed to “reset” disrupted brain circuits involved in depression, helping patients experience relief even when traditional antidepressants haven’t worked.
2. Unique Administration Method
Unlike oral medications, Spravato is administered as a nasal spray in our Denver office under medical supervision. This method allows the treatment to enter your system quickly and may help it act faster than pills that need to be digested and metabolized.
3. Rapid Onset of Effect
Traditional antidepressants can take 4–6 weeks to show results. Spravato, however, has been shown in studies to offer noticeable improvements within hours to days after treatment. For individuals experiencing severe or treatment-resistant depression, this faster response can be life-changing.
4. Supervised and Personalized Treatment
Because Spravato is a controlled medication, it’s administered in a certified treatment center like Peak Interactive Wellness. Each session includes monitoring by trained professionals, ensuring both safety and optimal results. After treatment, most patients spend about two hours resting comfortably before returning home with a designated driver.
Who Is a Good Candidate for Spravato?
Spravato may be a good option for you if you:
- Have tried two or more antidepressants without adequate relief
- Experience treatment-resistant depression
- Need a faster-acting option for severe depressive symptoms
Our Denver-based providers will conduct a thorough evaluation to determine whether Spravato is a safe and effective fit for your unique needs.
Why Choose Spravato Treatment in Denver at Peak Interactive Wellness
At Peak Interactive Wellness, we provide a comprehensive and compassionate approach to mental health care. Our Spravato treatment program integrates medication management with therapy, mindfulness, and holistic strategies to ensure your care is well-rounded and personalized.
Located conveniently in Denver and Greenwood Village, our certified providers deliver Spravato in a calm, supportive environment designed to promote healing and safety.
Take the Next Step Toward Relief
If you’re in Denver, Colorado, and struggling with depression that hasn’t improved with traditional medications, Spravato may be the solution you’ve been searching for.
To learn more about whether Spravato is right for you, call Peak Interactive Wellness at (720) 460-9084 or request an appointment online today.
You deserve relief — and innovative, compassionate care can help you find it.
Frequently Asked Questions About Spravato™ in Denver
Is Spravato™ the same as ketamine?
Spravato™ (esketamine) is a specific form of ketamine that has been FDA-approved for treatment-resistant depression. While both Spravato and traditional ketamine target the same NMDA receptors in the brain, Spravato is administered as a nasal spray in a controlled clinical setting and follows strict safety protocols under medical supervision.
How long does Spravato™ take to work?
Unlike traditional antidepressants that may take weeks to show results, many people experience noticeable improvement in mood, energy, or outlook within hours or days after their first Spravato session. Response times vary, and ongoing sessions typically help maintain and strengthen results.
Who can prescribe Spravato™ in Denver?
Spravato can only be prescribed and administered by certified healthcare providers through a REMS (Risk Evaluation and Mitigation Strategy)–approved clinic. At Peak Interactive Wellness in Denver, our licensed psychiatric providers are certified to safely administer Spravato and provide comprehensive follow-up care.
How is Spravato™ treatment administered?
Spravato is a nasal spray treatment that you self-administer under the supervision of a trained medical professional at our Denver office. Each session lasts about two hours, including monitoring and recovery time, ensuring your safety and comfort throughout the process.
Does insurance cover Spravato™ treatment?
Many insurance providers, including major plans in Colorado, cover Spravato™ for treatment-resistant depression when medical criteria are met. Our administrative team at Peak Interactive Wellness helps patients navigate insurance authorization and out-of-pocket costs before starting treatment.
What should I expect during my first Spravato™ session?
Your first Spravato treatment at Peak Interactive Wellness in Denver begins with a brief evaluation by your provider. You’ll self-administer the nasal spray under supervision, then relax in a quiet, comfortable setting while our team monitors your vitals and overall well-being. After the session, you’ll need a trusted person to drive you home.
Is Spravato™ right for me?
If you’ve tried multiple antidepressants without relief, or if you’re seeking a fast-acting, evidence-based treatment for depression, Spravato may be an excellent option. Our Denver-based team will evaluate your history, current symptoms, and goals to determine whether this treatment aligns with your needs.
Where can I receive Spravato™ treatment in Denver?
You can receive Spravato treatment at Peak Interactive Wellness, located in Denver and Greenwood Village, Colorado. Our certified providers deliver Spravato in a calm, supportive environment, combining innovation with compassionate care to help you rediscover balance and hope.
Ready to explore Spravato™ in Denver?
Contact Peak Interactive Wellness at (720) 460-9084 or schedule your consultation online. We’ll guide you through the process and help determine whether Spravato is the right next step in your mental health journey.
